Let's Give a PEP Talk! An Antiretroviral Therapy for HIV Prevention

welcome back to the mystifying medicine

series today we'll be talking about post

exposure prophylaxis which is a possible

trainer for HIV if taken immediately

after exposure if you want to learn more

about HIV please visit the demystifying

medicine page or click the video link

below let's give a pep talk meet Joe Joe

is a young adult and like most young

adults Joe likes to party

occasionally Joe meets a special friend

when he goes el and if he's really lucky

to decide to come home with them like

tonight let's not get into too much

detail what happens next you get the

idea the next morning Joe wakes up and

goes about his normal routine later that


Joe attends a dhimmis of my medicine

class where he watches the video book

HIV Joe Panik when he remembers he did

not use a condom last night and I sex

with a complete stranger ball in class

Joe runs to the nearest sexual health

clinic where he explains his worries to

the doctor the doctor tells him about

post-exposure prophylaxis also call me

known as path the doctor's planes that

path is a form of antiretroviral therapy

PAP is taken orally and the current most

common prescribed form pep consists of

one dose of Truvada and two doses of the

centrist which are taken daily Truvada

is a reverse transcriptase inhibitor

meaning inhibiting inversion of the

viral RNA to viral DNA where the

centrist is an integration hibbett er

which prevents a viral DNA from being

integrated into the genomic DNA of the


both these mechanisms are important in

the reproduction of the HIV virus within

the immune cell but with the help of pap

the production of the HIV virus is

suppressed the doctor warns Joe that

according to a case control study not on

health care workers exposed to HIV

positive blood through either a needle

or sharp object found that a similar

reverse transcriptase inhibitor 0vu 9 is

only about 81% of

but to reach this level of effectiveness

it must be taken for all 28 days and

treatment must be started within 72

hours of exposure he is also called he

needs to come back after six weeks and

four months from mandatory HIV antibody

testing after he prescribed a peb Joe

first relieved and decisive stick to the

28-day routine while on ped Joe realized

that it's not always sunshine and

daisies since during the medication he's

experienced side effects such as

abdominal pains headaches rashes

diarrhea and husband fatigue although

Joel's result ended up being negative

half for the four-month mandatory HIV

antibody testing it is still recommended

that PAP is only taken in emergency

situations practicing safe sex with the

use of condoms and using per minute of

exposure for faxes are more effective at

ensuring that HIV is not transmitted at

the end of the day be like Joe contact a

health care professional when in doubt

an discover what options are available

for you a message

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