FET or frozen embryo transfer is associated with an almost 10% better
chance for pregnancy than fresh transfer
The benefit is thought to be in the
preparation of the uterus
But what is the best way to prepare the uterus?
Find out in today's episode of infertility TV
In order to prepare the uterus for implantation, you need two hormones
Estrogen and progesterone.
Simply put, the estrogen makes the uterine lining thicker
and progesterone changes the lining so it can accept an embryo.
The most common method for uterine preparation has a woman taking
medications containing estrogen and progesterone to prepare the uterus.
The estrogen is given commonly by a pill orally but can also be given vaginally.
Some doctors like to give estrogen patches or even estrogen injections
progesterone is given typically as a vaginal suppository in combination with
Less commonly, doctors may choose to use the estrogen and progesterone
that a woman makes naturally when she develops an egg and ovulates.
This is known as Natural Cycle FET
Obviously, if a woman does not ovulate, this is not an option.
Which way is better?
Several studies have compared the two methods. As happens many times with
medical studies, the studies did not all agree on the same conclusion.
In other words, some studies indicated that natural cycle FET was better;
some studies concluded that hormone FET was better
and some said it didn't matter.
When this happens, we at InfertilityTV will look for a type of study called a meta-analysis.
With a meta-analysis, multiple smaller studies can be combined into one larger study.
The greater number of patients studied, the greater the chance that you will get valid conclusions
So, in 2019, a group of doctors from Brazil
performed a meta-analysis comparing natural cycle FET to hormone FET
In the end, the meta-analysis looked at
five studies involving nearly 9,000 FET cycles
What did they find?
Neither the natural cycle or hormone prepared FET could be proven to be better
Our InfertilityTV bottom line:
If you are planning to do an FET cycle,
its probably okay to choose either one of these methods.
However, I will point out
that doing a natural cycle can be much more difficult
because of the close monitoring that is required
to determine the exact time of ovulation.
For these reasons, at IVF1, we prefer to do FET cycles with hormone preparation.
For more important information about FET cycles
make sure you check out this playlist.
If you liked this video, remember to "LIKE" this video
Have a question? leave it in the comments below
Click the link in the description
to become a new patient or just subscribe to get new episodes weekly
It's like having an infertility specialist in your phone